Curing Cancer With Immunotherapy - General discussion READ-ONLY due to excessive spam

Cancer Research

Dadoona — Thu, 02 Aug 2018 09:51:01 +0000

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Hi Renee and Edward
Just came across this news today and thought of you both! You may be interested in having a read and give us your thoughts. It's great to see that Australian scietiists are working tirelessly to hopefully one day eradicate or at the very least control the spread of cancer in the body.

https://www.nature.com/articles/s41586-018-0387-5.epdf?referrer_access_t...

Interferon Gamma assay

Ramesh Dengwekar — Mon, 09 Jul 2018 08:23:03 +0000

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Hi Renee,

In your book you mentioned that you did a Interferon gamma assay as advised by Dr Old. What exactly was inferred from that ? Are there any references which can give us some more information regarding interpretation of the same in the context of immunotherapy ?

Regards

Side effects of Nivolumab

Ray — Sun, 08 Jul 2018 07:25:38 +0000

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Dear Rene and Edward Chee,

My NSCLC progressed after my 10th (20 weeks) Nivolumab infusion (mono therapy). To-date, I have done 15th Nivo infusion (as of June 20th).
My Oncologist has paused the Nivo treatment pending further biopsy test results. Thus far, I have experienced significant mouth ulcers and in my recent CT scan of July 4th,
mesenteric panniculitis was evident. Do you think the mesenteric inflammation & ulcers are associated with the Nivo treatment?. With this in mind, is it advisable to start Rene's regime of high dose omega 3?. Would high dose omega 3 exacerbate my current situation?.

As always, thank you in advance for your help.

Sincerely,
Raymond

Coleys in 2018

ellios — Fri, 29 Jun 2018 00:32:08 +0000

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Hi Rene,

I have read your book in just a few hours and I am delighted you seem to have beaten dreadful odds. May you live many more decades. You are a true inspiration. So, for the rest of us still in the struggle in 2018, where can we get a hold of Coleys toxin in 2018?

I am writing to you from Canada. Knowing that BMVax is out of business now and that, for my particular case, I am a melanoma stage 3b, at best stage 2b with ridiculous odds of recurrence after 20 months since diagnosis living in Quebec, Canada where standard of care is still in the dark ages (latest adjuvant trials confirmed at ESCO in Spain last September 2017 confirms that the right way to go is Opdivo for immune therapy of the Braf inhibitors if you have that mutation - which 8 don’t seem to have), how do I treat myself with the Coleys toxin? Where do I find it besides Chipsa hospital in Tijuana (where I went last January and came back two days later after seeing how they are ripping people off) or maybe Oasis of Hope in Cancun (where I suspect the same thing is goins on - without mentioning your own experience there!!!) Is there a way to get a reliable toxin source nowadays?

I do not have access to Opdivo as adjuvant in Quebec today. It will likely be years before it is approved as adjuvant for my case where I live. So, Coleys or I sell everything I own to try and buy it out of pocket not knowing if it will ever work? Cause we know the response rates. I am a firm believer about priming the immune system as you reported in your book - before going immune therapy. How to go about it today though??? I am fighting to just stay in the fight! Not even knowing if anything can work! Just wanting to stay in the arena! So any up-to-date information coming from you would be welcomed Rene. Off-label does not exist here in Canada. Public health systems are the opposite of your private one in the US. Same goes for the UK.

Where can I get a reliable coleys toxin today in 2018 for my personal use? I will do whatever necessary to inject it IV in myself; that’s a given.

Your help is invaluable. Thank you fot having shown the way so early in this new path of cancer CURE! I also have to point out that I am NOT eligible for clinical trials at the moment nor will be in the future because of a low genetic platelet condition. What else is left besides Coleys and some vaccine priming solution I should get somewhere

Dog Sarcoma/ Immunotherapy/ Omega 3

Rene and Edward Chee — Tue, 12 Jun 2018 22:15:36 +0000

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Question:

emhartley1
Sarcoma
Hello,
I'm so grateful that you have shared your experience with us through your book. This might seem unorthodox but I have been reading and researching in order to help my dog who has a high grade sarcoma. Chapter 15 inspired me to have him on high dosage of Omega 3 and low omega-6. I know you are not a vet but if we pretend that my dog is human I would really appreciate your help. He did get an immunotherapy vaccine one week ago. It was not until today that I logged on to your forum and red that you do not recommend high dosages of Omega 3 while on immunotherapy. It doesn't seem that many people or vets know much about immunotherapy for dogs so I've been doing my own research and my own reading and making my own decisions. So now I am very upset and feel I could have just ruined my chance to help my dog. I will quit the high dosage of Omega 3 today but just wondering if you have any feedback. Could you explain why Omega 3 should not be used with immunotherapy? Thank you so much.

Answer:

The reason we do not recommend omega 3 with immunotherapy: http://curingcancerbook.com/can-fish-oil-induce-chemoresistance

That said, we would not worry too much about the omega 3 negating the immunotherapy, since you've already taken action to stop the high omega 3. Also, our recommendation of not taking omega 3 during immunotherapy is based on our theoretical understanding and being over cautious. The immune response is very complex and we don't have actual experience that omega 3 negates immunotherapy.

We're curious what immunotherapy vaccine did your dog receive?

We hope your dog does very well on immunotherapy.

Metastasised Uterine Sarcoma

taylorj09 — Tue, 12 Jun 2018 15:01:39 +0000

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In September 2009 I was diagnosed with undifferentiated round cell sarcoma of the uterus (endometrium) for which I underwent a total abdominal hysterectomy with bilateral salpingo-oophorectomy. I had remained in remission until July 2014 when a CT scan revealed that I had a nodule in the base of my left lung (lingula). In September 2014 this was removed via thoracoscopic surgery and was later confirmed to be metastatic sarcoma.

A further nodule on the right lung was monitored which grew from 8mm to 9mm from December 2014 to April 2015. Additionally, a CT scan in April 2015 revealed 2 areas of focal pleural thickening which was considered to be pleural metastases. This pleural metastases was shown to have worsened in June 2015, with added left-sided pleural effusion. It was felt that the disease was not sufficiently developed enough to warrant treatment with chemotherapy at this stage. However, a CT scan in September 2015 had shown significant progression with an increase in the size of the left-sided pleural effusion and also associated increase in the left pleural metastatic disease. There was also an ill-defined soft tissue lesion within the subcutaneous tissue at the left lateral chest wall, which also increased in size likely to represent a subcutaneous metastasis.

In September of 2015 I had the pleural fluid of my left lung drained and began a 6-cycle course of palliative doxorubicin (75 mg/m2, reduced after the first cycle to 60 mg/m2) the following month. The course was stopped after the 5th cycle due to increased concern of a possible cardiac event. This chemotherapy was nevertheless generally effective, with a CT scan in March 2016 showing that the disease was stable.

The disease remained stable until a CT scan in June 2017 showed progression in the left basal pleural mass, and a node in the left hilar (very close to the pulmonary artery and aorta) which was also considered to be a metastases. I agreed to start a course of Trabectedin whilst trying to get on an immunotherapy trial using Olaratumab or Pembrolizumab, but I was deemed not eligible for either trial. A biopsy of the plural metastasis was consistent with a high-grade endometrial stromal sarcoma.

I began my course of Trabectedin in September 2017 (via 24 hour infusion). I was also given palliative radiotherapy (16 Gy in 2 fractions) to control haemoptysis stemming from the pulmonary metastases. The course of Trabectedin ceased after the 2nd cycle due to the contraction of a mycobacterium chelonae infection of my PICC line which required a 4 week course of antibiotics (Clarithromycin and Linezolid). However, between September 2017 and February 2018 the sarcoma had again stabilised in response to the Trabectedin and radiotherapy.

However, a CT scan in May 2018, revealed that the current tumours had begun to grow again and I am soon to begin a course of Trabectedin.

Judging my from case do you think I would be a good candidate for immunotherapy? If so which treatment would you suggest?

Thankyou very much for any assistance you can give me.

Kind regards,

Lorraine

Cryoablation with intratumoral immunotherapy and immunomodulatory chemo VS. German - Austria - Swiss clincs - hyperthermia etc

Rabia — Tue, 05 Jun 2018 21:13:18 +0000

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Dear Renee
Thank you for your outstanding and compassionate work to help all of us.

I'm dealing with breast cancer with possible spread to lungs - no one explained to me after months of tests and coughing blood and difficult breathing and chest pressure and pain and back pain that despite scans being somewhat ok without metastatic indication that I could indeed have something called lymphagenic metastases in the lungs (it took a German doctor to figure this out after over 20 doctors here in the US are baffled). This is a grim prognosis. I have ground glass opacities, largest 7mm, no consolidation. Bronchoscopy yielded no information. Nothing shows on PET scan. Yet apparently I can still have this going on and I am going downhill and terrified, and trying to remain calm.

Many questions:
I don't know if i can talk about a doctor by name....anyhow, there is a US based doctor. He takes patients to Mexico City for this therapy I am supposed to do: cryoablation with intratumoral injection of immunotherapies. A Stanford study showed remission (complete) in mice using OXC40 and CPG. My injections would be OX40, Resiquimod and Yervoy. The tumor is 3cm large, hard, pulling in at the skin breast tumor. Been there for 2 years. No biopsy but clearly malignant according to everyone based on PET and what it looks like now - very bad. The doctor wants me on cyclophosphamide - 50 mg every other day for at least 3 months. This is supposed to deplete tregs and skew immune to th1 dominance. Problem: I cannot find outcomes on his patients. He is elusive with this data and claims records are gone mostly. The ones I have tracked down had to do several treatments at exhorbitant prices. I have found little success. The Ox40 protocol has only been available since Feb. He says CPG not available but I found it for sale from biotech - maybe it is a different form - I don't know, I'm not a scientist. This doctor appears to be a genius, but I am afraid it will not work or make me worse, because the few people I tracked down online had not had success or had to go back again and again and I cannot afford this. I found only one metastatic breast patient - had one treatment - she is cancer free now three years later. But this can happen even conventional treatment....One woman - had just cryo - lived 11 years. Yet I have a woman who did cryo with a Michigan doctor who is 16 years out and she had breast already moved into lymph nodes. She did only cryo and radiation. I've learned cryo can sometimes push immune ) csystem to eradicate mets, but sometimes (often???) can actually be neutral or promote mets. I am very ill (I have late stage lyme and severe CFS and adrenal insufficiency and more problems), and afraid I will be a treatment failure. Do you have any advice on this treatment and if it sounds likely to work? Can I speak with you privately - or anyone on here that has thoughts on this? I'm a bit frazzled with fear so not doing things properly probably with regard to forum rules, so please instruct me if I am making errors and I will fix them. Can I talk about doctors by names?

I have looked into German clinics - using hyperthermia with low dose chemo and other alternative things. They seem to have more documented results. I have one lump of money to use and cannot make the wrong choice. I also think I must act very fast. I am totally alone and this is overwhelming to do alone. I am not sure I can do it.

I went to Mexico for treatment from doctor above last week and my procedure was cancelled last minute and I'm supposed to go back in two weeks to try again (too long to recount all the details). But as I track down more "lack of success" stories I'm getting more and more confused and scared. Also this doctor does not answer my questions to my satisfaction, but I do ask a lot of questions - yet, it is my life. The German clinics doctors have been MUCH more responsive and kind.

I took one dose of cyclo and had rectal bleeding. Also breathing got worse. I read in rare cases it can cause irreversible pulmonary fibrosis, sometimes YEARS after treatment. It is not known to be dose dependent, although clearly one would think higher dose would be worse. I took one 50mg pill and had rectal bleeding. I don't know what to think about this. I am more afraid of the lung problem as I am in total hell with the chest issues and breathing problems - it is terrifying and the worse thing that has happened to me. Again, we don't know for sure, but more doctors are now considering this lymphagenic lung mets as possible for me, maybe probable. And there are not more tests to do other than try a transbronchial biopsy which I don't really want to do as the pulmonologist tells me now that they don't even know where to biopsy and it could come up negative and still be actually that I have this. So why go through it if it may yield no results. And also, would only scare me more as it does not alter what I'm planning as I'm moving ahead with the assumption that I do have lung involvement anyway. Bizarely, the coughing stopped almost entirely, yet the breathing is worse. I don't know what to make of this situation.

I also have now resorted to low doses of xanax, adderrall and percocet. I co-dose with microgram range of naltrexone (lower than ULDN) as studies show it can reduce tolerance and dependence and side-effects. I don't think this is good for cancer (I know it is is not). But I am going out of my mind otherwise and the stress it too much for me anymore. Any thoughts on this I would also appreciate. I was experimenting with LDN, seem to get worse....and now seeing it is maybe moving people to th2 dominance, so that would be the opposite of what you want for cancer - right? So how does LDN work for cancer...doesn't seem clear to me anymore.

I'm taking so many supplements, doing mistletoe injections, tons of medicines.....afraid to go back on cyclophosphamide due to lungs and the bleeding incident...don't know if I should go back to mexico for the treatment as described or go to german clinic.....or go to german clinic then go to regular cryoablation without the injections. A german clinic doctor was familiar with the Stanford mice "cancer vaccine" (the basis of my upcoming treatment) and he warned me against it, saying it is speculation and it is experimentation and could make things much worse.

Forgive me for this rambling - if you can offer any advice - could I also tell you what I'm taking and you tell me if anything should be stopped...I will put a list iright here:

Thank you for any advice you can offer...if I can talk to you or email direct, please let me know although I understand this is probably not something you can do!
God bless you.
- Rabia

Supplements

Turkey Tail Host Defense
Life Extension European Milk Thistle - 60 pills - $18.99
Solgar CoQ10 400mg
Country Life NAC - 60 pills - $15,99
Bluebonnet Betaine HCl plus Pepsin - 90 pills - $16.99
Life Extension NK Cell Activator - 30 pills - $30.99
I-P6 & Inositol - 120 pills -
Twinlab Betaine HcL - 100 pills - $11.89
Symbiotic Lactoferrin - $47.99
Quality of Life Kinko Gold AHCC - $49.99
Life Extension Super Bio Curcumin - $15.99
Life Extension Gamma E Mixed Tocoperols
Fruitrientx Sea Buckthorn - 60 pills - $14.99
Solgar Vitamin C with Rose Hips - (add Bioflavanoids) - 1500mg
Life Extension Digestive Enzymes - 60 pills - $14.99
Now brand EGCG (Green Tea Extract) - 400mg
Jarrow Brand NAC - 500mg - 100 pills - $11.99
Sutherlander OTC (Oleander capsules from South America)
Arteminisin

Vitamins
B vitamins
B1 - Thiamine
B3 - Niacin
B5 - Pantothenic Acid
B12 - methylcobalumin
(no b vitamins now)
Alpha Lipoic Acid
Serrapeptase, Nattokinase, Lumbrokinase
Vitamin C (L-Ascorbate)
Vitamin A
Cellect vitamin powder with cod-liver oil
sporadic high dose fish oils

Diet right now - anything goes, but mostly organic, mostly vegetarian
sporadic flaxseed and cottage cheese

Other
Viscum Mali (mistletoe sub-q injections)
Pectasol
Diatomaceous Earth
Concentrace Minerals
Probiotics
Quinton Marine (not now)
Macrolife Naturals - Macrogreens Superfood - 30 svgs
Frankincense (topical and internal)
Sandalwood (internal)
Tea Tree Oil (internal)
Mucuna Pruriens (replace dopamine)
Quinine Sulfate? Chloroquine? (not now)

Medicines:
Xanax, Percocet, Amphetamine Salts, Valium, Marinol, medical cannabis (all very low dose as needed) - co-dose with NAC and ULDN
Hydrocortisone (for adrenal insufficiency) - 10mg - am, 5mg, afternoon, 5mg, night
Metformin

Dr. Supplements (planned cryo with intratumoral immunotherapy treatment upcoming in two weeks)
Low Dose Aspirin
Cialis (not yet)
Januvia (not yet)
Cyclophosphamide (stopped for now - 50mg pill every other day - 3-6 mos)
Protonix
Cranberry
Sulforophane
Turmeric
Probiotics
Cashews
EGCG

Type of Synovial Sarcoma

Dadoona — Thu, 24 May 2018 01:02:31 +0000

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Hi!
Ive read your book and posted in the past so thanks again. My partner had chest wall SS since 1 year ago and her treatment has included chaemo,surgery, radiotherapy and more chaemo all of this ended Sept 2017. She gets checked every 4 months with scans - Oct 2017, Feb 2018 - both clear! Next one due June 20th. She has been on fish oil and neuromins since October 2017.
Her SS diagnosis was bisaphic SSX1. I've done lots of research and it appears there is much confusion and most of the research seems to indicate that Bisaphic is favourable over Monosaphic but SSX1 appears to have a much worse prognosis however most Bisaphic is SSX1 which seems contradictory - do you have any thoughts on this? Also can i ask what your tumour diagnosis was - Bisaphic or Monosaphic and SSX1 or SSX2?
Also how are you doing? Well i hope!
Are you still taking the oils? How is patient DH? Do you know if he is still taking the oils after all these years?
Again thankyou for all that you've done to help everyone!

T- cell reaction with chemo and hyperthermia vs cryo

Job — Mon, 21 May 2018 15:33:02 +0000

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Dear Rene and Edwar,

Thank you so much for writing such an inspiring book, hope you all doing well!

At this moment I feel my synovial sarcoma is growing, I'm considering chemo, because I think it takes to long for getting PD-1 and Cryo, I would just win some time and prevent the tumor from invade other bone and tissue. Since I don't have detectable metastasis it's hard to get immunotherapy.

Q1: Still I think the chemo could spread the cancerous cells easily by suppressing the immune system. This is just a guess because every story I've read about synovial sarcoma treated with chemo, recurrence or metastasis occurs.

Q2: Since doxorubicin an ifosfamide will destroy all the cells, how could any T-cell recognise the dead cancer cells, so they can kill other cancer cells?

Q3: Are all the immune remembering T-cells destroyed after chemo, so I will get sick from a flu which I was already resistant for, also do I need to get new vaccines against Hepatitis etc?

Q4: Could hyperthermia get the same results as cryo? As far as I understand it works basically in the same way, while hyperthermia is easier to obtain and much cheaper. My tumor invaded my sitbone and is growing towards my anus, so I would also be able to use a thermo pad for locally heat the cancerous area.

Could you please give me some answers, I would really appreciate it!

All the best,
Job

Unclassified High Grade Neck Sarcoma

Alexander — Mon, 14 May 2018 01:08:51 +0000

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Hello, I recently had a 5.5 centimeter high grade pleomorphic sarcoma removed from under my sternocleidomastoid muscle at Stanford University. The tumor was removed in its full capsule with some surrounding soft tissue. All margins were declared free from tumor. The genetic testing is currently underway to determine if they can further classify my tumor but as of now it is unclassified by immunostains. They want me to undergo radiation and possibly chemo as these are standard treatments for what I had. The PET scan prior to surgery showed only localized disease. I do not want to undergo radiation or chemo because of side effects and would like to fight any microscopic disease by improving my immune system. I am doing coffee enemas which seems to help my colon rid endotoxins. I am doing a high omega 3 low omega 6 diet and restricting my sugar intake. I am juicing everyday and using essential oils, meditation, exercising-yoga, walks, light weight lifting etc. Sleeping 10 hours a day and taking medicinal mushrooms. I do not want to go through chemo and radiation at this stage right after my surgery because I feel like it will lower my immune system and its chances of fighting off any microscopic disease. The surgical margins were close and they were able to spare my nerve and artery near the tumor but the tumor was well circumscribed and remained encapsulated (as Ive said already). I am hopeful that surgery was a cure. Although I am aware of the high chance of recurrence given the high grade and size of my tumor. Do you think I can be cured by surgery alone and by doing what I can at home with diet and exercise to remain NED long term? I know that is an impossible question to answer but any advice from you would be very much appreciated. I have read your book. Thank you

Curing Cancer With Immunotherapy - General discussion *READ-ONLY* due to excessive spam

Cancer Research

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Interferon Gamma assay

Forums

Side effects of Nivolumab

Forums

Coleys in 2018

Forums

Dog Sarcoma/ Immunotherapy/ Omega 3

Forums

Metastasised Uterine Sarcoma

Forums

Cryoablation with intratumoral immunotherapy and immunomodulatory chemo VS. German - Austria - Swiss clincs - hyperthermia etc

Forums

Type of Synovial Sarcoma

Forums

T- cell reaction with chemo and hyperthermia vs cryo

Forums

Unclassified High Grade Neck Sarcoma

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Curing Cancer With Immunotherapy - General discussion READ-ONLY due to excessive spam