Curing Cancer With Immunotherapy - Off-label Immunotherapy READ-ONLY due to excessive spam

looking for doctors that are willing to prescribe off-label immunotherapy in breast cancer

osteokp — Mon, 13 Aug 2018 11:22:55 +0000

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Off-label Immunotherapy *READ-ONLY* due to excessive spam

Hi there Guys,

I am looking for any recommendations for doctors are that are willing to prescribe off-labeled immunotherapy for breast cancer. I am really hopeful.
xxx

Pd1 Myxoid Liposarcoma

CfIrl — Wed, 13 Dec 2017 20:46:53 +0000

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Off-label Immunotherapy *READ-ONLY* due to excessive spam

Hi Everyone,

I had a radiation & excision of a myxoid liposarcoma tumour last year. I was NED for 10 months until I had back problems which turned out to be a recurrence & bone mets. As it turns out it was 'just hiding'. So I'm looking at my options for palliative chemo or immunotherapy.

My oncologist has ordered gene testing to establish the PD1 possibilities. My first oncologist wanted dox/ifos so I went for a second opinion. Dox/olara was approved in the UK June of this year but isn't yet in Ireland where I am. There are options but they mainly seem to be approved as second line treatment after anthracycline.

A lot depends on the outcome of the gene testing but I'm considering self funding olaratumab (dox is covered by insurance) as a first line. I'm 35, no underlying conditions & no mets anywhere other than my lumbar, so I'm as able as I'm ever going to be for a hard chemo regimen.

Playing the long game here, I'm considering this as my first step so I don't have any more problems than necessary with approval for second line treatments which have been mentioned like trabectedin, pembrolizumab & various others. Most seem to require previous anthracyclines & I don't want to have to battle for each new drug when the time comes. Time & relative health are on my side now so I don't want to paint myself into a corner.

Hypothetically where would you start? Dox/olara & then move onto the less debilitating & perhaps more promising lines of treatment? Or go straight to the PD1 route?

My onc is all about immunotherapy which is great but I have to think about funding & approvals & using my current health to my advantage in the long run.

Any suggestions or advice?

Thank you

Clare.

Road to Yervoy or Opdivo

mikesther79 — Fri, 29 Jul 2016 07:21:56 +0000

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Off-label Immunotherapy *READ-ONLY* due to excessive spam

Dear Dr. Chee,

Thank you so much for sharing your life's battle with us in your amazing book. I downloaded it yesterday and am now all the way to chapter 9. Ever since January of this year, I had begun to hope and believe that my 7 yr-old daughter's immune system would one day eradicate her biphenotypic leukemia (ALL+AML expressed in each blast). Your book quickly confirmed and helped solidify this assertion. I am confident that her cure will come through immunotherapy. (The clinical advice is to achieve remission and head straight for a second bone marrow transplant.)

I have a connection at BMS that is working to help get us either Yervoy or Opdivo. Until then, we need to "buy some time." We recently finished a course of medium intensity Mylotarg w/Cytarabine and there's now only one very small lung nodule left and her bone marrow has 0.09% blasts. (She used to be "chock full" of tumors with 40% blasts in the peripheral blood.) By Friday of this week, we need to decide whether to repeat Mylotarg, this time with a hi intensity backbone of fludarabine and cytarabine, or to give Venetoclax a try, which is a BCL-2 inhibitor.

If all roads (hopefully) lead to PD-1 inhibitor or CTLA-4 inhibitor, or even Notch-1 inhibitor (our daughter has the Notch-1 mutation), I'm wondering what you would recommend between these two current options. Or, do you have any other recommendation?

Our problem with high intensity Mylotarg is that it would cripple her immune system and leave her vulnerable to infection - a 60% likelihood. I feel that this is dangerous because if we do get past that round and end up receiving immunotherapy, we want her immune function to be strong rather than traumatized, right? The upside to high intensity chemo is that it should keep the disease at bay and prevent relapse in the CNS and skin. (Ava originally relapsed after transplant in the skin, and just more recently in the CNS. But all of it has cleared after total skin electron therapy and further chemo.)

Our concern with Venetoclax is that she would be only the 2nd child to have received it, and we are uncertain of the efficacy since there is no pediatric data. Clinical trials are set to begin in the 4th quarter. I understand from mouse models that Venetoclax does not cross the blood brain barrier. So if it the treatment is ineffective, she might be vulnerable to CNS or even skin relapse, both of which have been very difficult to deal with.

The compromise to either option would be to use Mylotarg with a lighter backbone such as Azacitidine, or if we go with Venetoclax, then to give her a dose of intrathecal chemo during the round.

I hope to finish your book by tomorrow, which will give me so many more insights. In the meantime, thank you so much for creating this forum for us!

So blessed by your unstoppable courage and impeccable work,

Mike

Curing Cancer With Immunotherapy - Off-label Immunotherapy *READ-ONLY* due to excessive spam

looking for doctors that are willing to prescribe off-label immunotherapy in breast cancer

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Pd1 Myxoid Liposarcoma

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Road to Yervoy or Opdivo

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Curing Cancer With Immunotherapy - Off-label Immunotherapy READ-ONLY due to excessive spam