Curing Cancer With Immunotherapy - Obtaining Immunotherapy Abroad READ-ONLY due to excessive spam

Coleys toxin in 2018

ellios — Mon, 25 Jun 2018 20:08:37 +0000

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Obtaining Immunotherapy Abroad *READ-ONLY* due to excessive spam

Hi Rene,

I have read your book in just a few hours and I am delighted you seem to have beaten dreadful odds. May you live many more decades. You are a true inspiration. So, for the rest of us still in the struggle in 2018, where can we get a hold of Coleys toxin in 2018?

I am writing to you from Canada. Knowing that BMVax is out of business now and that, for my particular case, I am a melanoma stage 3b, at best stage 2b with ridiculous odds of recurrence after 20 months since diagnosis living in Quebec, Canada where standard of care is still in the dark ages (latest adjuvant trials confirmed at ESCO in Spain last September 2017 confirms that the right way to go is Opdivo for immune therapy of the Braf inhibitors if you have that mutation - which 8 don’t seem to have), how do I treat myself with the Coleys toxin? Where do I find it besides Chipsa hospital in Tijuana (where I went last January and came back two days later after seeing how they are ripping people off) or maybe Oasis of Hope in Cancun (where I suspect the same thing is goins on - without mentioning your own experience there!!!) Is there a way to get a reliable toxin source nowadays?

I do not have access to Opdivo as adjuvant in Quebec today. It will likely be years before it is approved as adjuvant for my case where I live. So, Coleys or I sell everything I own to try and buy it out of pocket not knowing if it will ever work? Cause we know the response rates. I am a firm believer about priming the immune system as you reported in your book - before going immune therapy. How to go about it today though??? I am fighting to just stay in the fight! Not even knowing if anything can work! Just wanting to stay in the arena! So any up-to-date information coming from you would be welcomed Rene. Off-label does not exist here in Canada. Public health systems are the opposite of your private one in the US. Same goes for the UK.

Where can I get a reliable coleys toxin today in 2018 for my personal use? I will do whatever necessary to inject it IV in myself; that’s a given.

Your help is invaluable. Thank you fot having shown the way so early in this new path of cancer CURE! I also have to point out that I am NOT eligible for clinical trials at the moment nor will be in the future because of a low genetic platelet condition. What else is left besides Coleys and some vaccine priming solution I should get somewhere?

Obtain Coley Toxin

Karemimmunotherapy — Mon, 07 Aug 2017 02:36:41 +0000

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Obtaining Immunotherapy Abroad *READ-ONLY* due to excessive spam

Hi Rene,

Thank you for the wonderful book. Your experience and persistence in fight cancer inspiring all of us.
I have er/pr + breast cancer IV. Have you heard
successful story using coley toxin against BC? Er/pr Breast cancer is known resistant to immunotherapy.
Since MBVax is no longer in business, do you know other channels to obtain coley toxin vaccine?

Thanks,
Karen

immunotherapy

ulian79 — Mon, 16 Jan 2017 16:43:21 +0000

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Obtaining Immunotherapy Abroad *READ-ONLY* due to excessive spam

Dear Rene

As you know I am trying to find a doctor who would be able to prescribe me either Keytruda or Optivo.
I just had a consultation with an oncologyst in Poland who told me that there are no research showing that Keytruda will help with Synovial Sarcoma.
He also said that if I want the best results I should be taking Keytruda together with Optivo.
Am I right to say that he is completely wrong as Keytruda and Optivo are the same drugs - PD-1 inhibitors and if anything he should have suggested taking Keytruda or Optivo with Yervoy?
Is it the ignorance of the doctors or they just do not want to share the knowledge they have?

I am having another meeting in London so fingers crossed it will be different.

Thank you
Urszula

Immunotherapy in Sydney/Australia

Ray — Sun, 15 Jan 2017 11:18:19 +0000

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Obtaining Immunotherapy Abroad *READ-ONLY* due to excessive spam

Dear Rene & Edward,
I had my right lower lobe lobectomy and left lower lobe resection performed on November 4 and November 11 2014 respectively. There were diagnosed as Stage 1B & 1A respectively. Due to its early stage, no adjuvant therapy was required. From the molecular tissue analysis, the right lung has no EGFR mutation (EGFR negative) and negative to ALK & ROS1 , while the left lung is positive to p.Leu858Arg (L858R) or Exon21 mutation. In my PET scan on December 5 2016, they detected a lesion (cancer) on my T1 Spinous Process, even though there is no other cancer detected else where in my body. Whilst a “cystic (9 mm)” and a “tiny nodular density (2 mm)” on the right middle lobe lung were mentioned in the PET, these were present since 12 October 2015 (via CAT imaging) [during that time, cyst was 3 mm & nodule was 2 mm] - my Thoracic surgeon told me in my meeting on 9 December 2016, not to worry about it as there were there since 12 October 2015 and no lung cancer was not evident on the PET dated 28 April 2016 & 5 December 2016. I underwent a resection of T1 Spinous Process on December 21 2016. From the T1 biopsy report, it is non mutated (EGFR negative), confirming the oligometastatic from my right lung.

Blood Test for EGFR T790M (Exon21 mutation) Mutation Analysis Report for T1 Spinous Process: Jan 6, 2017, performed at Olivia Newton-John Cancer Research Institute.
INTERPRETATION: Plasma DNA is a surrogate for tumour DNA. The absence of the EGFR T790M mutation in the blood does not rule out the possibility that the tumour may harbour the EGFR T790M mutation, especially since the EGFR driver mutation was not detected. This may be due to a low tumour burden. Thus, EGFR mutation testing of tumour tissue is required to exclude the presence of the mutation. If a tissue biopsy is not possible, a blood sample from this patient could be sent to us again when the tumour burden increases. My Oncologist told me that the Circulating Tumour DNA originally proposed to be done at MSKCC may bear similar results as the above and he believes this is a good result because it showed low circulating tumour burden.

I will be undergoing IMRT 30 Gy in 10 fractions over 10 days to treat the T1 Spinous Process in the next 1-2 weeks and my Oncologist recommended Chemo as well. This first line therapy is Carboplatin/Alimta for 4 cycles over a 12 week duration (1 cycle every 3 weeks) to wipe out the remaining circulating tumour before they multiply. My Oncologist cousin in Yale Comprehensive Cancer Center agreed with my Sydney Oncologist that it is potentially curable, so aggressive treatment with radiation and chemotherapy makes sense. In fact, my Oncologist did mention to do IMRT & Chemo together - I am very weary my body just can not handle these combined toxicities.

Q1: After reading your Chapter 2 & 3, I am beginning to doubt if Chemo will actually provide me with a cure?. In other words, would it just delay the inevitable recurrence of cancer?.
Looking at a back-up plan in the event the recurrence happens after Chemo, would immunotherapy still works as effective as if I have not done Chemo (I suppose this is exactly what Rene has been through)?.

Q2: How is Rene's recent neutrophil count when compared with the time she underwent Chemo?. Is Rene's bone marrow back to normal when compared with the time prior to Chemo?. Does Rene have any further side effects as a result of the Chemo?.

Q3: With my non-mutated mets to T1, do you think immunotherapy still provide a higher chances of cure when compared with Chemo?.
My Oncologist mentioned that if Chemo doesn't work (recurrence of cancer), then immunotherapy can be used as a second line therapy.

Q4: What immunotherapy is Rene currently on?.

My Chemo decision time is coming up in a week time - I am just not sure what to do honestly as I have not found a cancer centre in Sydney/Australia that can offer immunotherapy and I am very weary of the lasting side effects Carboplatin/Alimta can have. Due to the time pressure and the thought of circulating tumour multiplying, I may be forced to bite the bullet and take the Chemo option.

FYI, I have stopped taking all my omega 3 high doses, vitamins & supplements in preparation for the IMRT.

Your feedback would be greatly valued & appreciated.

Thank you

Immunotherapy in Canada?

Rene and Edward Chee — Sun, 07 Aug 2016 05:56:22 +0000

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Obtaining Immunotherapy Abroad *READ-ONLY* due to excessive spam

Questions asked by a reader regarding a colon cancer patient:

Past treatments:
- primary tumor surgically removed, followed by chemotherapy (fluorouracil, oxaliplatin, leucovorin), that led to side effect of persistent numbness in hands and feet
- 1 metastatic lung tumor surgically removed (1cm)

Current tumor situation:
- 3 metastatic lung nodules (3-5mm each)
- 1 possible metastatic liver lesion
- MMR (mismatch repair) normal

Current treatment:
- chemotherapy (Capecitabine) - not curative, as it will only reduce the recurrence of colon cancer by 5-10%

1) What immunotherapies are available in Canada, specifically in Vancouver, British Columbia?

2) Any thoughts on an immunotherapy strategy with respect to an article from Science Daily, June 29, 2016, titled "Anti-PD-L1 immunotherapy responsive in microsatellite-stable mCRC comb with MEK inhibition."

Answer:

There are 2 main points I would like to highlight from the article "Anti-PD-L1 immunotherapy responsive in microsatellite-stable mCRC comb with MEK inhibition." you referenced:

1) “Microsatellite instability-high colorectal cancers are associated with a greater number of mutations and are therefore more responsive to immunotherapy with PD-L1/PD-1 blockade.”

If the patient shows high mutations, they will most likely be more responsive to immunotherapy as the tumor looks more “foreign” than normal cells. Thus, if the tumor has problems with the mismatch repair genes, thus generating more mutations, the tumor will elicit a stronger immune response. However, this patient has normal mismatch repair (MMR) genes.

But, the fact that the tumors are still growing after having gone through a chemotherapy regimen may imply that the current tumors are accumulating more mutations. Thus, this patient’s tumors may have enough mutations to elicit an immune response.

2) “Preclinical studies have suggested that a MEK inhibitor can make a tumor more responsive to immunotherapy by increasing the number of active immune cells -- such as CD8+ cells -- in the tumor, and increasing the expression of factors that cause the immune system to be more active.”

DHA, which is a component of fish oil (discussed in Chapter 15 as a form of dietary immunotherapy), and can be gotten from algae oil, may act as a MEK inhibitor, as discussed in this paper (http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3179420/) So perhaps the omega 3-6 diet discussed in Chapter 15 may be an easier way to obtain the same effect as MEK inhibitors.

Also, the patient has 4 tumors: 3 lung nodules and 1 in the liver. These tumors can be killed with cryoablation (Chapter 11 and Chapter 14). This not only kills the tumor, but leverages the dead tumor as a cancer vaccine, to train the immune system to recognize the cancer as “the bad guy”, which is a very important component of immunotherapy. Even if the tumor doesn’t have enough mutations (as discussed above), the high inflammation caused by the cryoablation at the site of the tumor will trigger the immune system to recognize the tumor as “foreign”.

The success of cryoablation and whether a difficult tumor can be cryoablated depends on the experience of the doctor performing the procedure. The most experienced cryoablation doctor in the US is Dr. Peter Littrup (Brown University, Providence, Rhode Island), who has treated patients from Vancouver, BC. There is also a doctor who does cryoablation in Vancouver, BC. He is not as experienced as Dr. Littrup, but may be able to treat tumors that are easier to treat and not in critical locations: Dr. David Liu, Vancouver General Hospital (http://doctor-finder.sirweb.org/details.cfm?xid=1067401) I would contact both doctors to see whether all 4 tumors can be cryoablated.

After soldier T cells are generated to attack the tumor (from cryoablations and DHA), immunotherapies such as PD-1 (discussed in Chapter 7) can complement the immune attack by removing the tumor defenses. PD-1 (Opdivo or Keytruda) is approved in Canada for other cancers (melanoma, lung cancer, bladder cancer, etc). You will need to ask doctors or medical professional in Canada whether doctors can prescribe PD-1 off-label, since it’s already been approved for several other cancers, just not colon cancer yet. If it is possible, you will need to look for a doctor who is willing to prescribe it.

Another way to obtain PD-1 would be to look for US clinical trials. I’ve heard it’s hard to get into PD-1 trials even for US patients, due to the large demand. But it’s worth a try to call the clinical trial contacts to see if the patient can qualify. Info to find US clinical trials are in Chapter 16 - especially look up the Cancer Research Institute Clinical Trial Finder.

Curing Cancer With Immunotherapy - Obtaining Immunotherapy Abroad *READ-ONLY* due to excessive spam

Coleys toxin in 2018

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Immunotherapy in Sydney/Australia

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Immunotherapy in Canada?

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Curing Cancer With Immunotherapy - Obtaining Immunotherapy Abroad READ-ONLY due to excessive spam