Dear Rene and Chee,
there was a study from Stanford that just came out and got a lot of publicity:
https://med.stanford.edu/news/all-news/2018/01/cancer-vaccine-eliminates...
Can I ask your thoughts on this? And if you think this is a promising approach, do you think it is something that could be possible to implement outside of a formal trial?
Best,
Lars
We've been following Ron Levy's work since 2012/2013. We talk about Dr. Levy's work in our book as well.
There are 2 key principles in this study that closely mimic Dr. William Coley's strategy from > 100 yrs ago
1) Direct injection of agonists into tumor (CpG is bacterial DNA signatures, similar to Coley's toxins)
2) Repeat injection (not concluding treatment is ineffective upon recurrence)
The late Dr. Lloyd Old (Father of modern cancer immunology) felt these principles were highly important. Unfortunately both these approaches aren't typical / compatible with modern oncology which seeks ease of application (intravenous) and usually concludes treatments are ineffective upon recurrence.
Thanks for this.
CpG: do you know if this is possible to get hold of anywhere? Any clinics offering it? Or possible to buy anywhere?
Lars
Lars, I am also interested in the same, as it seems something that could be easily implemented in any clinics in Europe.
I know both the SD-101 and the Anti OX-40 can be purchased easily. The point is finding a structure willing to do it.
I believe William cancer institute does the CPG/ox40 protocol, I am planning to head there please let me know if anyone else has more information on this clinic.
Hello Maya - may I know how you go with William cancer institute (that does the CPG/ox40 protocol)?.
Thanking you in advance.
Raymond
Sorry i did not go for it as its very experimental and dont know if anyone has success with it
Maya,
Can you email me or let me know how to email you. Would love to connect regarding Dr Williams!
If you find a place/way to implement it, then do let me know. Definitely interested in this too!
Another option that someone alerted me to is this one:
Low-dose inhalation of interleukin-2 bio-chemotherapy for the treatment of pulmonary metastases in melanoma patients.
https://www.ncbi.nlm.nih.gov/pubmed/24518593
It is not exactly intratumoral injection. And it is not these new "fancy" compounds. However, inhalation in the way described in the article should be possible to be repeated. And it is more targeted than intravenous, at least if we are talking about lung metastasis.
Lars